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Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. Ac...

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Autores principales: Chi, Minghan, Qi, Manlin, A, Lan, Wang, Ping, Weir, Michael D., Melo, Mary Anne, Sun, Xiaolin, Dong, Biao, Li, Chunyan, Wu, Junling, Wang, Lin, Xu, Hockin H. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359151/
https://www.ncbi.nlm.nih.gov/pubmed/30641958
http://dx.doi.org/10.3390/ijms20020278
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author Chi, Minghan
Qi, Manlin
A, Lan
Wang, Ping
Weir, Michael D.
Melo, Mary Anne
Sun, Xiaolin
Dong, Biao
Li, Chunyan
Wu, Junling
Wang, Lin
Xu, Hockin H. K.
author_facet Chi, Minghan
Qi, Manlin
A, Lan
Wang, Ping
Weir, Michael D.
Melo, Mary Anne
Sun, Xiaolin
Dong, Biao
Li, Chunyan
Wu, Junling
Wang, Lin
Xu, Hockin H. K.
author_sort Chi, Minghan
collection PubMed
description Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures.
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spelling pubmed-63591512019-02-06 Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms Chi, Minghan Qi, Manlin A, Lan Wang, Ping Weir, Michael D. Melo, Mary Anne Sun, Xiaolin Dong, Biao Li, Chunyan Wu, Junling Wang, Lin Xu, Hockin H. K. Int J Mol Sci Review Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures. MDPI 2019-01-11 /pmc/articles/PMC6359151/ /pubmed/30641958 http://dx.doi.org/10.3390/ijms20020278 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chi, Minghan
Qi, Manlin
A, Lan
Wang, Ping
Weir, Michael D.
Melo, Mary Anne
Sun, Xiaolin
Dong, Biao
Li, Chunyan
Wu, Junling
Wang, Lin
Xu, Hockin H. K.
Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title_full Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title_fullStr Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title_full_unstemmed Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title_short Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms
title_sort novel bioactive and therapeutic dental polymeric materials to inhibit periodontal pathogens and biofilms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359151/
https://www.ncbi.nlm.nih.gov/pubmed/30641958
http://dx.doi.org/10.3390/ijms20020278
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