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Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin...

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Detalles Bibliográficos
Autores principales: Shrestha, Sanjay, Hazelbaker, Mark, Yount, Amber L., Walczak, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359247/
https://www.ncbi.nlm.nih.gov/pubmed/30577528
http://dx.doi.org/10.3390/biom9010001
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author Shrestha, Sanjay
Hazelbaker, Mark
Yount, Amber L.
Walczak, Claire E.
author_facet Shrestha, Sanjay
Hazelbaker, Mark
Yount, Amber L.
Walczak, Claire E.
author_sort Shrestha, Sanjay
collection PubMed
description Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.
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spelling pubmed-63592472019-02-11 Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation Shrestha, Sanjay Hazelbaker, Mark Yount, Amber L. Walczak, Claire E. Biomolecules Review Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization. MDPI 2018-12-20 /pmc/articles/PMC6359247/ /pubmed/30577528 http://dx.doi.org/10.3390/biom9010001 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shrestha, Sanjay
Hazelbaker, Mark
Yount, Amber L.
Walczak, Claire E.
Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title_full Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title_fullStr Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title_full_unstemmed Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title_short Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation
title_sort emerging insights into the function of kinesin-8 proteins in microtubule length regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359247/
https://www.ncbi.nlm.nih.gov/pubmed/30577528
http://dx.doi.org/10.3390/biom9010001
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