Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture

Endogenous γ-aminobutyric acid (GABA)-dependent activity induces death of developing Purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. Here, using brain-derived neurotrophic factor (BDNF) heterozygous mice, we show that BDNF plays no...

Descripción completa

Detalles Bibliográficos
Autores principales: Rakotomamonjy, Jennifer, Ghoumari, Abdel Mouman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359295/
https://www.ncbi.nlm.nih.gov/pubmed/30642045
http://dx.doi.org/10.3390/ijms20020285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359295/
https://www.ncbi.nlm.nih.gov/pubmed/30642045
http://dx.doi.org/10.3390/ijms20020285

Ejemplares similares