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Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer

l-asparaginase (ASNase) is a metabolism-targeted anti-neoplastic agent used to treat acute lymphoblastic leukemia (ALL). ASNase’s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are converted to aspartic acid (Asp) and glutamic acid (Glu), resp...

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Detalles Bibliográficos
Autores principales:	Horvath, Thomas D., Chan, Wai Kin, Pontikos, Michael A., Martin, Leona A., Du, Di, Tan, Lin, Konopleva, Marina, Weinstein, John N., Lorenzi, Philip L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359345/ https://www.ncbi.nlm.nih.gov/pubmed/30634463 http://dx.doi.org/10.3390/metabo9010010

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