Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility

Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher es...

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Detalles Bibliográficos
Autores principales: He, Xin, Yang, Jing, Qiu, Ling, Feng, Dan, Ju, Feng, Tan, Lu, Li, Yu-Zhi, Gu, Yu-Cheng, Zhang, Zhen, Guo, Da-Le, Deng, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359346/
https://www.ncbi.nlm.nih.gov/pubmed/30650614
http://dx.doi.org/10.3390/molecules24020299
Descripción
Sumario:Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system.

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