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Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility
Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher es...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359346/ https://www.ncbi.nlm.nih.gov/pubmed/30650614 http://dx.doi.org/10.3390/molecules24020299 |
| _version_ | 1783392221888774144 |
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| author | He, Xin Yang, Jing Qiu, Ling Feng, Dan Ju, Feng Tan, Lu Li, Yu-Zhi Gu, Yu-Cheng Zhang, Zhen Guo, Da-Le Deng, Yun |
| author_facet | He, Xin Yang, Jing Qiu, Ling Feng, Dan Ju, Feng Tan, Lu Li, Yu-Zhi Gu, Yu-Cheng Zhang, Zhen Guo, Da-Le Deng, Yun |
| author_sort | He, Xin |
| collection | PubMed |
| description | Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system. |
| format | Online Article Text |
| id | pubmed-6359346 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63593462019-02-06 Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility He, Xin Yang, Jing Qiu, Ling Feng, Dan Ju, Feng Tan, Lu Li, Yu-Zhi Gu, Yu-Cheng Zhang, Zhen Guo, Da-Le Deng, Yun Molecules Article Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system. MDPI 2019-01-15 /pmc/articles/PMC6359346/ /pubmed/30650614 http://dx.doi.org/10.3390/molecules24020299 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article He, Xin Yang, Jing Qiu, Ling Feng, Dan Ju, Feng Tan, Lu Li, Yu-Zhi Gu, Yu-Cheng Zhang, Zhen Guo, Da-Le Deng, Yun Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title | Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title_full | Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title_fullStr | Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title_full_unstemmed | Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title_short | Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility |
| title_sort | thiodiketopiperazines produced by penicillium crustosum and their activities to promote gastrointestinal motility |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359346/ https://www.ncbi.nlm.nih.gov/pubmed/30650614 http://dx.doi.org/10.3390/molecules24020299 |
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