Cargando…

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain,...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiyani, Mubin Mustafa, Sohail, Muhammad Farhan, Shahnaz, Gul, Rehman, Hamza, Akhtar, Muhammad Furqan, Nawaz, Irum, Mahmood, Tariq, Manzoor, Mobina, Imran Bokhari, Syed Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359362/
https://www.ncbi.nlm.nih.gov/pubmed/30642012
http://dx.doi.org/10.3390/medicina55010010
_version_ 1783392226274967552
author Kiyani, Mubin Mustafa
Sohail, Muhammad Farhan
Shahnaz, Gul
Rehman, Hamza
Akhtar, Muhammad Furqan
Nawaz, Irum
Mahmood, Tariq
Manzoor, Mobina
Imran Bokhari, Syed Ali
author_facet Kiyani, Mubin Mustafa
Sohail, Muhammad Farhan
Shahnaz, Gul
Rehman, Hamza
Akhtar, Muhammad Furqan
Nawaz, Irum
Mahmood, Tariq
Manzoor, Mobina
Imran Bokhari, Syed Ali
author_sort Kiyani, Mubin Mustafa
collection PubMed
description Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities.
format Online
Article
Text
id pubmed-6359362
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63593622019-02-13 Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug Kiyani, Mubin Mustafa Sohail, Muhammad Farhan Shahnaz, Gul Rehman, Hamza Akhtar, Muhammad Furqan Nawaz, Irum Mahmood, Tariq Manzoor, Mobina Imran Bokhari, Syed Ali Medicina (Kaunas) Article Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities. MDPI 2019-01-11 /pmc/articles/PMC6359362/ /pubmed/30642012 http://dx.doi.org/10.3390/medicina55010010 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kiyani, Mubin Mustafa
Sohail, Muhammad Farhan
Shahnaz, Gul
Rehman, Hamza
Akhtar, Muhammad Furqan
Nawaz, Irum
Mahmood, Tariq
Manzoor, Mobina
Imran Bokhari, Syed Ali
Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title_full Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title_fullStr Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title_full_unstemmed Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title_short Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
title_sort evaluation of turmeric nanoparticles as anti-gout agent: modernization of a traditional drug
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359362/
https://www.ncbi.nlm.nih.gov/pubmed/30642012
http://dx.doi.org/10.3390/medicina55010010
work_keys_str_mv AT kiyanimubinmustafa evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT sohailmuhammadfarhan evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT shahnazgul evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT rehmanhamza evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT akhtarmuhammadfurqan evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT nawazirum evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT mahmoodtariq evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT manzoormobina evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug
AT imranbokharisyedali evaluationofturmericnanoparticlesasantigoutagentmodernizationofatraditionaldrug