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Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug
Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359362/ https://www.ncbi.nlm.nih.gov/pubmed/30642012 http://dx.doi.org/10.3390/medicina55010010 |
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author | Kiyani, Mubin Mustafa Sohail, Muhammad Farhan Shahnaz, Gul Rehman, Hamza Akhtar, Muhammad Furqan Nawaz, Irum Mahmood, Tariq Manzoor, Mobina Imran Bokhari, Syed Ali |
author_facet | Kiyani, Mubin Mustafa Sohail, Muhammad Farhan Shahnaz, Gul Rehman, Hamza Akhtar, Muhammad Furqan Nawaz, Irum Mahmood, Tariq Manzoor, Mobina Imran Bokhari, Syed Ali |
author_sort | Kiyani, Mubin Mustafa |
collection | PubMed |
description | Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities. |
format | Online Article Text |
id | pubmed-6359362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63593622019-02-13 Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug Kiyani, Mubin Mustafa Sohail, Muhammad Farhan Shahnaz, Gul Rehman, Hamza Akhtar, Muhammad Furqan Nawaz, Irum Mahmood, Tariq Manzoor, Mobina Imran Bokhari, Syed Ali Medicina (Kaunas) Article Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities. MDPI 2019-01-11 /pmc/articles/PMC6359362/ /pubmed/30642012 http://dx.doi.org/10.3390/medicina55010010 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kiyani, Mubin Mustafa Sohail, Muhammad Farhan Shahnaz, Gul Rehman, Hamza Akhtar, Muhammad Furqan Nawaz, Irum Mahmood, Tariq Manzoor, Mobina Imran Bokhari, Syed Ali Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title | Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title_full | Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title_fullStr | Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title_full_unstemmed | Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title_short | Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug |
title_sort | evaluation of turmeric nanoparticles as anti-gout agent: modernization of a traditional drug |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359362/ https://www.ncbi.nlm.nih.gov/pubmed/30642012 http://dx.doi.org/10.3390/medicina55010010 |
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