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Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359471/ https://www.ncbi.nlm.nih.gov/pubmed/30646552 http://dx.doi.org/10.3390/metabo9010014 |
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author | Lu, Yonghai Wang, Yeli Liang, Xu Zou, Li Ong, Choon Nam Yuan, Jian-Min Koh, Woon-Puay Pan, An |
author_facet | Lu, Yonghai Wang, Yeli Liang, Xu Zou, Li Ong, Choon Nam Yuan, Jian-Min Koh, Woon-Puay Pan, An |
author_sort | Lu, Yonghai |
collection | PubMed |
description | We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population. |
format | Online Article Text |
id | pubmed-6359471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63594712019-02-11 Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population Lu, Yonghai Wang, Yeli Liang, Xu Zou, Li Ong, Choon Nam Yuan, Jian-Min Koh, Woon-Puay Pan, An Metabolites Article We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population. MDPI 2019-01-14 /pmc/articles/PMC6359471/ /pubmed/30646552 http://dx.doi.org/10.3390/metabo9010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lu, Yonghai Wang, Yeli Liang, Xu Zou, Li Ong, Choon Nam Yuan, Jian-Min Koh, Woon-Puay Pan, An Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title | Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title_full | Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title_fullStr | Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title_full_unstemmed | Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title_short | Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population |
title_sort | serum amino acids in association with prevalent and incident type 2 diabetes in a chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359471/ https://www.ncbi.nlm.nih.gov/pubmed/30646552 http://dx.doi.org/10.3390/metabo9010014 |
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