Cargando…

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at lea...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamichhane, Santosh, Ahonen, Linda, Sparholt Dyrlund, Thomas, Dickens, Alex M., Siljander, Heli, Hyöty, Heikki, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyötyläinen, Tuulia, Knip, Mikael, Oresic, Matej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359525/
https://www.ncbi.nlm.nih.gov/pubmed/30669674
http://dx.doi.org/10.3390/biom9010033
_version_ 1783392273995661312
author Lamichhane, Santosh
Ahonen, Linda
Sparholt Dyrlund, Thomas
Dickens, Alex M.
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
author_facet Lamichhane, Santosh
Ahonen, Linda
Sparholt Dyrlund, Thomas
Dickens, Alex M.
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
author_sort Lamichhane, Santosh
collection PubMed
description Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
format Online
Article
Text
id pubmed-6359525
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63595252019-02-11 Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes Lamichhane, Santosh Ahonen, Linda Sparholt Dyrlund, Thomas Dickens, Alex M. Siljander, Heli Hyöty, Heikki Ilonen, Jorma Toppari, Jorma Veijola, Riitta Hyötyläinen, Tuulia Knip, Mikael Oresic, Matej Biomolecules Article Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR. MDPI 2019-01-21 /pmc/articles/PMC6359525/ /pubmed/30669674 http://dx.doi.org/10.3390/biom9010033 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lamichhane, Santosh
Ahonen, Linda
Sparholt Dyrlund, Thomas
Dickens, Alex M.
Siljander, Heli
Hyöty, Heikki
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Hyötyläinen, Tuulia
Knip, Mikael
Oresic, Matej
Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title_full Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title_fullStr Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title_full_unstemmed Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title_short Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
title_sort cord-blood lipidome in progression to islet autoimmunity and type 1 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359525/
https://www.ncbi.nlm.nih.gov/pubmed/30669674
http://dx.doi.org/10.3390/biom9010033
work_keys_str_mv AT lamichhanesantosh cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT ahonenlinda cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT sparholtdyrlundthomas cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT dickensalexm cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT siljanderheli cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT hyotyheikki cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT ilonenjorma cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT topparijorma cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT veijolariitta cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT hyotylainentuulia cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT knipmikael cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes
AT oresicmatej cordbloodlipidomeinprogressiontoisletautoimmunityandtype1diabetes