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Simultaneous Quantitation of a Novel α(1)/β(1)-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

TJ0711∙HCl, which is a novel α(1)/β(1) adrenoceptor blocking agent with a ratio of 1:1 for α(1)/β(1), is designed to treat and prevent perioperative hypertension. M1 and M3 were identified as important metabolites in vitro for either antihypertension activity or the major metabolite production. In o...

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Detalles Bibliográficos
Autores principales:	Zhu, Wenwen, Liu, Wanyu, Li, Haojv, Xu, Guojia, Li, Qian, Huang, Jiangeng, Li, Gao, Si, Luqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359546/ https://www.ncbi.nlm.nih.gov/pubmed/30669292 http://dx.doi.org/10.3390/pharmaceutics11010038

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