Magnetofluorescent Nanocomposite Comprised of Carboxymethyl Dextran Coated Superparamagnetic Iron Oxide Nanoparticles and β-Diketon Coordinated Europium Complexes

Red emitting europium (III) complexes Eu(TFAAN)(3)(P(Oct)(3))(3) (TFAAN = 2-(4,4,4-Trifluoroacetoacetyl)naphthalene, P(Oct)(3) = trioctylphosphine) chelated on carboxymethyl dextran coated superparamagnetic iron oxide nanoparticles (CMD-SPIONs) was synthesized and the step wise synthetic process was reported. All the excitation spectra of distinctive photoluminesces were originated from f-f transition of Eu(III) with a strong red emission. The emission peaks are due to the hypersensitive transition (5)D(0)→(7)F(2) at 621 nm and (5)D(0)→(7)F(1) at 597 nm, (5)D(0)→(7)F(0) at 584 nm. No significant change in PL properties due to addition of CMD-SPIONs was observed. The cytotoxic effects of different concentrations and incubation times of Eu(TFAAN)(3)(P(Oct)(3))(3) chelated CMD-SPIONs were evaluated in HEK293T and HepG2 cells using the WST assay. The results imply that Eu(TFAAN)(3)(P(Oct)(3))(3) chelated CMD-SPIONs are not affecting the cell viability without altering the apoptosis and necrosis in the range of 10 to 240 μg/mL concentrations.