Cargando…
A Review on Bioactivities of Tobacco Cembranoid Diterpenes
Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cem...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359560/ https://www.ncbi.nlm.nih.gov/pubmed/30654586 http://dx.doi.org/10.3390/biom9010030 |
_version_ | 1783392288037142528 |
---|---|
author | Yan, Ning Du, Yongmei Liu, Xinmin Zhang, Hongbo Liu, Yanhua Zhang, Zhongfeng |
author_facet | Yan, Ning Du, Yongmei Liu, Xinmin Zhang, Hongbo Liu, Yanhua Zhang, Zhongfeng |
author_sort | Yan, Ning |
collection | PubMed |
description | Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships. |
format | Online Article Text |
id | pubmed-6359560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63595602019-02-11 A Review on Bioactivities of Tobacco Cembranoid Diterpenes Yan, Ning Du, Yongmei Liu, Xinmin Zhang, Hongbo Liu, Yanhua Zhang, Zhongfeng Biomolecules Review Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships. MDPI 2019-01-16 /pmc/articles/PMC6359560/ /pubmed/30654586 http://dx.doi.org/10.3390/biom9010030 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yan, Ning Du, Yongmei Liu, Xinmin Zhang, Hongbo Liu, Yanhua Zhang, Zhongfeng A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title_full | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title_fullStr | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title_full_unstemmed | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title_short | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
title_sort | review on bioactivities of tobacco cembranoid diterpenes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359560/ https://www.ncbi.nlm.nih.gov/pubmed/30654586 http://dx.doi.org/10.3390/biom9010030 |
work_keys_str_mv | AT yanning areviewonbioactivitiesoftobaccocembranoidditerpenes AT duyongmei areviewonbioactivitiesoftobaccocembranoidditerpenes AT liuxinmin areviewonbioactivitiesoftobaccocembranoidditerpenes AT zhanghongbo areviewonbioactivitiesoftobaccocembranoidditerpenes AT liuyanhua areviewonbioactivitiesoftobaccocembranoidditerpenes AT zhangzhongfeng areviewonbioactivitiesoftobaccocembranoidditerpenes AT yanning reviewonbioactivitiesoftobaccocembranoidditerpenes AT duyongmei reviewonbioactivitiesoftobaccocembranoidditerpenes AT liuxinmin reviewonbioactivitiesoftobaccocembranoidditerpenes AT zhanghongbo reviewonbioactivitiesoftobaccocembranoidditerpenes AT liuyanhua reviewonbioactivitiesoftobaccocembranoidditerpenes AT zhangzhongfeng reviewonbioactivitiesoftobaccocembranoidditerpenes |