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A Review on Bioactivities of Tobacco Cembranoid Diterpenes

Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cem...

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Autores principales: Yan, Ning, Du, Yongmei, Liu, Xinmin, Zhang, Hongbo, Liu, Yanhua, Zhang, Zhongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359560/
https://www.ncbi.nlm.nih.gov/pubmed/30654586
http://dx.doi.org/10.3390/biom9010030
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author Yan, Ning
Du, Yongmei
Liu, Xinmin
Zhang, Hongbo
Liu, Yanhua
Zhang, Zhongfeng
author_facet Yan, Ning
Du, Yongmei
Liu, Xinmin
Zhang, Hongbo
Liu, Yanhua
Zhang, Zhongfeng
author_sort Yan, Ning
collection PubMed
description Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships.
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spelling pubmed-63595602019-02-11 A Review on Bioactivities of Tobacco Cembranoid Diterpenes Yan, Ning Du, Yongmei Liu, Xinmin Zhang, Hongbo Liu, Yanhua Zhang, Zhongfeng Biomolecules Review Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships. MDPI 2019-01-16 /pmc/articles/PMC6359560/ /pubmed/30654586 http://dx.doi.org/10.3390/biom9010030 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Ning
Du, Yongmei
Liu, Xinmin
Zhang, Hongbo
Liu, Yanhua
Zhang, Zhongfeng
A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title_full A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title_fullStr A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title_full_unstemmed A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title_short A Review on Bioactivities of Tobacco Cembranoid Diterpenes
title_sort review on bioactivities of tobacco cembranoid diterpenes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359560/
https://www.ncbi.nlm.nih.gov/pubmed/30654586
http://dx.doi.org/10.3390/biom9010030
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