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Chemistry of Bridged Lactams: Recent Developments

Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special...

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Autores principales: Szostak, Roman, Szostak, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359620/
https://www.ncbi.nlm.nih.gov/pubmed/30642094
http://dx.doi.org/10.3390/molecules24020274
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author Szostak, Roman
Szostak, Michal
author_facet Szostak, Roman
Szostak, Michal
author_sort Szostak, Roman
collection PubMed
description Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures.
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spelling pubmed-63596202019-02-06 Chemistry of Bridged Lactams: Recent Developments Szostak, Roman Szostak, Michal Molecules Review Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures. MDPI 2019-01-12 /pmc/articles/PMC6359620/ /pubmed/30642094 http://dx.doi.org/10.3390/molecules24020274 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szostak, Roman
Szostak, Michal
Chemistry of Bridged Lactams: Recent Developments
title Chemistry of Bridged Lactams: Recent Developments
title_full Chemistry of Bridged Lactams: Recent Developments
title_fullStr Chemistry of Bridged Lactams: Recent Developments
title_full_unstemmed Chemistry of Bridged Lactams: Recent Developments
title_short Chemistry of Bridged Lactams: Recent Developments
title_sort chemistry of bridged lactams: recent developments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359620/
https://www.ncbi.nlm.nih.gov/pubmed/30642094
http://dx.doi.org/10.3390/molecules24020274
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