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Chemistry of Bridged Lactams: Recent Developments
Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359620/ https://www.ncbi.nlm.nih.gov/pubmed/30642094 http://dx.doi.org/10.3390/molecules24020274 |
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author | Szostak, Roman Szostak, Michal |
author_facet | Szostak, Roman Szostak, Michal |
author_sort | Szostak, Roman |
collection | PubMed |
description | Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures. |
format | Online Article Text |
id | pubmed-6359620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63596202019-02-06 Chemistry of Bridged Lactams: Recent Developments Szostak, Roman Szostak, Michal Molecules Review Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures. MDPI 2019-01-12 /pmc/articles/PMC6359620/ /pubmed/30642094 http://dx.doi.org/10.3390/molecules24020274 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szostak, Roman Szostak, Michal Chemistry of Bridged Lactams: Recent Developments |
title | Chemistry of Bridged Lactams: Recent Developments |
title_full | Chemistry of Bridged Lactams: Recent Developments |
title_fullStr | Chemistry of Bridged Lactams: Recent Developments |
title_full_unstemmed | Chemistry of Bridged Lactams: Recent Developments |
title_short | Chemistry of Bridged Lactams: Recent Developments |
title_sort | chemistry of bridged lactams: recent developments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359620/ https://www.ncbi.nlm.nih.gov/pubmed/30642094 http://dx.doi.org/10.3390/molecules24020274 |
work_keys_str_mv | AT szostakroman chemistryofbridgedlactamsrecentdevelopments AT szostakmichal chemistryofbridgedlactamsrecentdevelopments |