A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq

BACKGROUND: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. METHODS: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatogra...

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Detalles Bibliográficos
Autores principales: Chemmugil, P, Lakshmi, PTV, Annamalai, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359695/
https://www.ncbi.nlm.nih.gov/pubmed/30800243
Descripción
Sumario:BACKGROUND: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. METHODS: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatography was subjected to antibacterial and anti-quorum sensing activity against S. aureus and Methicillin Resistant Staphylococcus aureus (MRSA). RESULTS: The obtained results confirmed fraction F44 to have significant effect as antimicrobial and anti-biofilm agent against both the micro-organism. Therefore, few of such highly active fractions were chemical finger printed using GC-MS and the compounds identified were further docked with DNA binding (LytTR) domain of agrA, which revealed that compounds identified from fraction were interactive to the protein. CONCLUSION: R. patula is promising antimicrobial and anti-biofilm agent against S. aureus and MRSA.

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