A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq

BACKGROUND: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. METHODS: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatogra...

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Detalles Bibliográficos
Autores principales: Chemmugil, P, Lakshmi, PTV, Annamalai, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359695/
https://www.ncbi.nlm.nih.gov/pubmed/30800243
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author Chemmugil, P
Lakshmi, PTV
Annamalai, A
author_facet Chemmugil, P
Lakshmi, PTV
Annamalai, A
author_sort Chemmugil, P
collection PubMed
description BACKGROUND: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. METHODS: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatography was subjected to antibacterial and anti-quorum sensing activity against S. aureus and Methicillin Resistant Staphylococcus aureus (MRSA). RESULTS: The obtained results confirmed fraction F44 to have significant effect as antimicrobial and anti-biofilm agent against both the micro-organism. Therefore, few of such highly active fractions were chemical finger printed using GC-MS and the compounds identified were further docked with DNA binding (LytTR) domain of agrA, which revealed that compounds identified from fraction were interactive to the protein. CONCLUSION: R. patula is promising antimicrobial and anti-biofilm agent against S. aureus and MRSA.
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spelling pubmed-63596952019-02-22 A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq Chemmugil, P Lakshmi, PTV Annamalai, A Avicenna J Med Biotechnol Original Article BACKGROUND: Staphylococcus aureus (S. aureus) causing numerous diseases in humans, have become resistant to antibiotics, hence, urging the need for alternative medicines. METHODS: In this study, the Indian medicinal weed, Ruellia patula (R. patula) extracted and fractioned through column chromatography was subjected to antibacterial and anti-quorum sensing activity against S. aureus and Methicillin Resistant Staphylococcus aureus (MRSA). RESULTS: The obtained results confirmed fraction F44 to have significant effect as antimicrobial and anti-biofilm agent against both the micro-organism. Therefore, few of such highly active fractions were chemical finger printed using GC-MS and the compounds identified were further docked with DNA binding (LytTR) domain of agrA, which revealed that compounds identified from fraction were interactive to the protein. CONCLUSION: R. patula is promising antimicrobial and anti-biofilm agent against S. aureus and MRSA. Avicenna Research Institute 2019 /pmc/articles/PMC6359695/ /pubmed/30800243 Text en Copyright© 2019 Avicenna Research Institute http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chemmugil, P
Lakshmi, PTV
Annamalai, A
A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title_full A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title_fullStr A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title_full_unstemmed A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title_short A Multidisciplinary Study to Evaluate the Anti-quorum Sensing Ability of Phyto-compounds in Ruellia patula Jacq
title_sort multidisciplinary study to evaluate the anti-quorum sensing ability of phyto-compounds in ruellia patula jacq
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359695/
https://www.ncbi.nlm.nih.gov/pubmed/30800243
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