Cargando…

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

Post-translational modifications of host or viral proteins are key strategies exploited by viruses to support virus replication and counteract host immune response. SUMOylation is a post-translational modification process mediated by a family of ubiquitin-like proteins called small ubiquitin-like mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Zheng, Chu, Hin, Wen, Lei, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Yuen, Terrence Tsz-Tai, Yip, Cyril Chik-Yan, Wang, Dong, Zhou, Jie, Yin, Feifei, Jin, Dong-Yan, Kok, Kin-Hang, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359730/ https://www.ncbi.nlm.nih.gov/pubmed/30658479 http://dx.doi.org/10.3390/ijms20020392

Ejemplares similares

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2018)

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
por: Zhang, Xi, et al.
Publicado: (2022)

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2016)

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets
por: Cao, Jianli, et al.
Publicado: (2021)

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells
por: Yang, Dong, et al.
Publicado: (2021)

1899. The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro
por: Chan, Jasper, et al.
Publicado: (2018)

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2016)

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)
por: Yuan, Shuofeng, et al.
Publicado: (2020)

918. Identification of novel druggable host targets for Middle East respiratory syndrome coronavirus using a quantitative phosphoproteomics approach
por: Chan, Jasper F W, et al.
Publicado: (2023)

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells
por: Zou, Zijiao, et al.
Publicado: (2020)

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study
por: Chu, Hin, et al.
Publicado: (2020)

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells
por: Yan, Bingpeng, et al.
Publicado: (2019)

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn
por: Yuan, Shuo-Feng, et al.
Publicado: (2021)

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2020)

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus
por: Yuan, Shuofeng, et al.
Publicado: (2019)

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor
por: Wen, Lei, et al.
Publicado: (2021)

Evaluation of simple nucleic acid extraction methods for the detection of SARS-CoV-2 in nasopharyngeal and saliva specimens during global shortage of extraction kits
por: Chu, Allen Wing-Ho, et al.
Publicado: (2020)

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant
por: Xia, Shuai, et al.
Publicado: (2022)

Clinical Performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 Detection in Nasopharyngeal Specimens from COVID-19 Patients in Hong Kong
por: Chen, Jonathan Hon-Kwan, et al.
Publicado: (2020)

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
por: Yuan, Shuofeng, et al.
Publicado: (2019)

Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway
por: Yan, Bingpeng, et al.
Publicado: (2022)

Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2022)

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
por: Li, Can, et al.
Publicado: (2021)

Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
por: Chan, Jasper F.W., et al.
Publicado: (2016)

A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant
por: Liu, Zezhong, et al.
Publicado: (2022)

Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2
por: Chen, Jonathan Hon-Kwan, et al.
Publicado: (2020)

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage
por: Liang, Ronghui, et al.
Publicado: (2022)

A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters
por: Zhang, Bao-Zhong, et al.
Publicado: (2021)

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity
por: Chu, Hin, et al.
Publicado: (2021)

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation
por: Zhang, Xi, et al.
Publicado: (2020)

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2020)

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly
por: Hu, Bodan, et al.
Publicado: (2022)

Targeting ACLY efficiently inhibits SARS-CoV-2 replication
por: Yuen, Terrence Tsz-Tai, et al.
Publicado: (2022)

Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain
por: Ip, Jonathan Daniel, et al.
Publicado: (2021)

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system
por: Yuan, Shuofeng, et al.
Publicado: (2020)

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target
por: Li, Cun, et al.
Publicado: (2020)

Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection
por: Yip, Cyril Chik-Yan, et al.
Publicado: (2020)

Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19)
por: Cheng, Vincent Chi-Chung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6u99vggs32h8h1pp44bgs085ok