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2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells

BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for...

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Detalles Bibliográficos
Autores principales:	Li, Wuguo, Zhang, Qing, Chen, Kaotan, Sima, Zhenhua, Liu, Jingli, Yu, Qiang, Liu, Jiawei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359800/ https://www.ncbi.nlm.nih.gov/pubmed/30709346 http://dx.doi.org/10.1186/s12906-019-2440-9

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