Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines

Breast cancer is the one of the most frequent causes of female cancer mortality. KDM5A, a histone demethylase, can increase the proliferation, metastasis, and drug resistance of cancers, including breast cancer, and is thus an important therapeutic target. In the present work, we performed hierarchi...

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Detalles Bibliográficos
Autores principales: Yang, Guan-Jun, Ko, Chung-Nga, Zhong, Hai-Jing, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360022/
https://www.ncbi.nlm.nih.gov/pubmed/30650517
http://dx.doi.org/10.3390/cancers11010092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360022/
https://www.ncbi.nlm.nih.gov/pubmed/30650517
http://dx.doi.org/10.3390/cancers11010092

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