Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway

AIM: To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis. METHODS: In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at the MOI of 1 : 40. Then, the phenotype (MHCII, CD80, a...

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Detalles Bibliográficos
Autores principales: Xu, Yejin, Tang, Xinyue, Yang, Min, Zhang, Shengguo, Li, Shanshan, Chen, Yukai, Liu, Minhui, Guo, Yuxiang, Lu, Mingqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360045/
https://www.ncbi.nlm.nih.gov/pubmed/30800002
http://dx.doi.org/10.1155/2019/4652596

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