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Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients
Ascorbate requiring Fe(2+)/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in the endomembranes of fibroblasts from arterial to...
Autores principales: | Németh, Csilla E., Nemoda, Zsófia, Lőw, Péter, Szabó, Pál, Horváth, Erzsébet Z., Willaert, Andy, Boel, Annekatrien, Callewaert, Bert L., Coucke, Paul J., Colombi, Marina, Bánhegyi, Gábor, Margittai, Éva |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360052/ https://www.ncbi.nlm.nih.gov/pubmed/30800210 http://dx.doi.org/10.1155/2019/8156592 |
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