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GRID-independent molecular descriptor analysis and molecular docking studies to mimic the binding hypothesis of γ-aminobutyric acid transporter 1 (GAT1) inhibitors
BACKGROUND: The γ-aminobutyric acid (GABA) transporter GAT1 is involved in GABA transport across the biological membrane in and out of the synaptic cleft. The efficiency of this Na(+) coupled GABA transport is regulated by an electrochemical gradient, which is directed inward under normal conditions...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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PeerJ Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360079/ https://www.ncbi.nlm.nih.gov/pubmed/30723616 http://dx.doi.org/10.7717/peerj.6283 |