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Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates

Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human KIR genes, which vary by presence and copy number, KIR3DL3 is ubiquitously present in every individual across diverse populations. No ligand or function is known for KIR3DL...

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Detalles Bibliográficos
Autores principales:	Leaton, Laura A., Shortt, Jonathan, Kichula, Katherine M., Tao, Sudan, Nemat-Gorgani, Neda, Mentzer, Alexander J., Oppenheimer, Stephen J., Deng, Zhihui, Hollenbach, Jill A., Gignoux, Christopher R., Guethlein, Lisbeth A., Parham, Peter, Carrington, Mary, Norman, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360152/ https://www.ncbi.nlm.nih.gov/pubmed/30745901 http://dx.doi.org/10.3389/fimmu.2019.00024

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