Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo

Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell...

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Autores principales: Xu, Li-Na, Zhao, Na, Chen, Jin-Yan, Ye, Piao-Piao, Nan, Xing-Wei, Zhou, Hai-Hong, Jiang, Qi-Wei, Yang, Yang, Huang, Jia-Rong, Yuan, Meng-Ling, Xing, Zi-Hao, Wei, Meng-Ning, Li, Yao, Shi, Zhi, Yan, Xiao-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360154/
https://www.ncbi.nlm.nih.gov/pubmed/30746340
http://dx.doi.org/10.3389/fonc.2019.00002
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author Xu, Li-Na
Zhao, Na
Chen, Jin-Yan
Ye, Piao-Piao
Nan, Xing-Wei
Zhou, Hai-Hong
Jiang, Qi-Wei
Yang, Yang
Huang, Jia-Rong
Yuan, Meng-Ling
Xing, Zi-Hao
Wei, Meng-Ning
Li, Yao
Shi, Zhi
Yan, Xiao-Jian
author_facet Xu, Li-Na
Zhao, Na
Chen, Jin-Yan
Ye, Piao-Piao
Nan, Xing-Wei
Zhou, Hai-Hong
Jiang, Qi-Wei
Yang, Yang
Huang, Jia-Rong
Yuan, Meng-Ling
Xing, Zi-Hao
Wei, Meng-Ning
Li, Yao
Shi, Zhi
Yan, Xiao-Jian
author_sort Xu, Li-Na
collection PubMed
description Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.
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spelling pubmed-63601542019-02-11 Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo Xu, Li-Na Zhao, Na Chen, Jin-Yan Ye, Piao-Piao Nan, Xing-Wei Zhou, Hai-Hong Jiang, Qi-Wei Yang, Yang Huang, Jia-Rong Yuan, Meng-Ling Xing, Zi-Hao Wei, Meng-Ning Li, Yao Shi, Zhi Yan, Xiao-Jian Front Oncol Oncology Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer. Frontiers Media S.A. 2019-01-28 /pmc/articles/PMC6360154/ /pubmed/30746340 http://dx.doi.org/10.3389/fonc.2019.00002 Text en Copyright © 2019 Xu, Zhao, Chen, Ye, Nan, Zhou, Jiang, Yang, Huang, Yuan, Xing, Wei, Li, Shi and Yan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xu, Li-Na
Zhao, Na
Chen, Jin-Yan
Ye, Piao-Piao
Nan, Xing-Wei
Zhou, Hai-Hong
Jiang, Qi-Wei
Yang, Yang
Huang, Jia-Rong
Yuan, Meng-Ling
Xing, Zi-Hao
Wei, Meng-Ning
Li, Yao
Shi, Zhi
Yan, Xiao-Jian
Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title_full Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title_fullStr Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title_full_unstemmed Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title_short Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
title_sort celastrol inhibits the growth of ovarian cancer cells in vitro and in vivo
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360154/
https://www.ncbi.nlm.nih.gov/pubmed/30746340
http://dx.doi.org/10.3389/fonc.2019.00002
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