Cargando…
Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma
BACKGROUND: The aim of this study was to investigate the relationship between EGFR mutation and computed tomography (CT) features in patients with adenocarcinoma of the lung. METHODS: One hundred and ninety two lung adenocarcinoma patients who underwent surgery were retrospectively included in this...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360198/ https://www.ncbi.nlm.nih.gov/pubmed/30516345 http://dx.doi.org/10.1111/1759-7714.12928 |
_version_ | 1783392425343975424 |
---|---|
author | Qiu, Xiaowei Yuan, Hang Sima, Bin |
author_facet | Qiu, Xiaowei Yuan, Hang Sima, Bin |
author_sort | Qiu, Xiaowei |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate the relationship between EGFR mutation and computed tomography (CT) features in patients with adenocarcinoma of the lung. METHODS: One hundred and ninety two lung adenocarcinoma patients who underwent surgery were retrospectively included in this study. Examination of EGFR gene mutation was performed on all resected tumor samples. The 192 recruited lung adenocarcinoma patients were divided into groups according to EGFR mutation status: patients with mutations in exons 18–21 (effective mutated, n = 61) and non‐mutated (n = 131). The clinical characteristics and lung CT imaging features of the two groups were recorded and compared. Univariate and logistic regression analysis were performed to identify the independent risk factors relevant to effective EGFR gene mutation. RESULTS: The independent risk factors relevant to effective EGFR mutation were evaluated by logistic regression test. The results indicated that female gender (odds ratio [OR] 3.23), lung CT features of lymphangitis carcinomatosa (OR 2.66), semi‐solid lesion density (OR 3.56), and spicule sign (OR 1.61) were independent risk factors relevant to EGFR mutation. CONCLUSION: Female patients with lung CT features of lymphangitis carcinomatosa, semi‐solid lesion density, and spicule sign are more prone to harbor EGFR gene mutations and are more likely to benefit from targeted therapy. |
format | Online Article Text |
id | pubmed-6360198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63601982019-02-14 Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma Qiu, Xiaowei Yuan, Hang Sima, Bin Thorac Cancer Original Articles BACKGROUND: The aim of this study was to investigate the relationship between EGFR mutation and computed tomography (CT) features in patients with adenocarcinoma of the lung. METHODS: One hundred and ninety two lung adenocarcinoma patients who underwent surgery were retrospectively included in this study. Examination of EGFR gene mutation was performed on all resected tumor samples. The 192 recruited lung adenocarcinoma patients were divided into groups according to EGFR mutation status: patients with mutations in exons 18–21 (effective mutated, n = 61) and non‐mutated (n = 131). The clinical characteristics and lung CT imaging features of the two groups were recorded and compared. Univariate and logistic regression analysis were performed to identify the independent risk factors relevant to effective EGFR gene mutation. RESULTS: The independent risk factors relevant to effective EGFR mutation were evaluated by logistic regression test. The results indicated that female gender (odds ratio [OR] 3.23), lung CT features of lymphangitis carcinomatosa (OR 2.66), semi‐solid lesion density (OR 3.56), and spicule sign (OR 1.61) were independent risk factors relevant to EGFR mutation. CONCLUSION: Female patients with lung CT features of lymphangitis carcinomatosa, semi‐solid lesion density, and spicule sign are more prone to harbor EGFR gene mutations and are more likely to benefit from targeted therapy. John Wiley & Sons Australia, Ltd 2018-12-05 2019-02 /pmc/articles/PMC6360198/ /pubmed/30516345 http://dx.doi.org/10.1111/1759-7714.12928 Text en © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Qiu, Xiaowei Yuan, Hang Sima, Bin Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title | Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title_full | Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title_fullStr | Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title_full_unstemmed | Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title_short | Relationship between EGFR mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
title_sort | relationship between egfr mutation and computed tomography characteristics of the lung in patients with lung adenocarcinoma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360198/ https://www.ncbi.nlm.nih.gov/pubmed/30516345 http://dx.doi.org/10.1111/1759-7714.12928 |
work_keys_str_mv | AT qiuxiaowei relationshipbetweenegfrmutationandcomputedtomographycharacteristicsofthelunginpatientswithlungadenocarcinoma AT yuanhang relationshipbetweenegfrmutationandcomputedtomographycharacteristicsofthelunginpatientswithlungadenocarcinoma AT simabin relationshipbetweenegfrmutationandcomputedtomographycharacteristicsofthelunginpatientswithlungadenocarcinoma |