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CircFunBase: a database for functional circular RNAs
Increasing evidence reveals that circular RNAs (circRNAs) are widespread in eukaryotes and play important roles in diverse biological processes. However, a comprehensive functionally annotated circRNA database is still lacking. CircFunBase is a web-accessible database that aims to provide a high-qua...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360206/ https://www.ncbi.nlm.nih.gov/pubmed/30715276 http://dx.doi.org/10.1093/database/baz003 |
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author | Meng, Xianwen Hu, Dahui Zhang, Peijing Chen, Qi Chen, Ming |
author_facet | Meng, Xianwen Hu, Dahui Zhang, Peijing Chen, Qi Chen, Ming |
author_sort | Meng, Xianwen |
collection | PubMed |
description | Increasing evidence reveals that circular RNAs (circRNAs) are widespread in eukaryotes and play important roles in diverse biological processes. However, a comprehensive functionally annotated circRNA database is still lacking. CircFunBase is a web-accessible database that aims to provide a high-quality functional circRNA resource including experimentally validated and computationally predicted functions. The current version of CircFunBase documents more than 7000 manually curated functional circRNA entries, mainly including Homo sapiens, Mus musculus etc. CircFunBase provides visualized circRNA-miRNA interaction networks. In addition, a genome browser is provided to visualize the genome context of circRNAs. As a biological information platform for circRNAs, CircFunBase will contribute for circRNA studies and bridge the gap between circRNAs and their functions. |
format | Online Article Text |
id | pubmed-6360206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63602062019-02-08 CircFunBase: a database for functional circular RNAs Meng, Xianwen Hu, Dahui Zhang, Peijing Chen, Qi Chen, Ming Database (Oxford) Database Tool Increasing evidence reveals that circular RNAs (circRNAs) are widespread in eukaryotes and play important roles in diverse biological processes. However, a comprehensive functionally annotated circRNA database is still lacking. CircFunBase is a web-accessible database that aims to provide a high-quality functional circRNA resource including experimentally validated and computationally predicted functions. The current version of CircFunBase documents more than 7000 manually curated functional circRNA entries, mainly including Homo sapiens, Mus musculus etc. CircFunBase provides visualized circRNA-miRNA interaction networks. In addition, a genome browser is provided to visualize the genome context of circRNAs. As a biological information platform for circRNAs, CircFunBase will contribute for circRNA studies and bridge the gap between circRNAs and their functions. Oxford University Press 2019-02-04 /pmc/articles/PMC6360206/ /pubmed/30715276 http://dx.doi.org/10.1093/database/baz003 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Tool Meng, Xianwen Hu, Dahui Zhang, Peijing Chen, Qi Chen, Ming CircFunBase: a database for functional circular RNAs |
title | CircFunBase: a database for functional circular RNAs |
title_full | CircFunBase: a database for functional circular RNAs |
title_fullStr | CircFunBase: a database for functional circular RNAs |
title_full_unstemmed | CircFunBase: a database for functional circular RNAs |
title_short | CircFunBase: a database for functional circular RNAs |
title_sort | circfunbase: a database for functional circular rnas |
topic | Database Tool |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360206/ https://www.ncbi.nlm.nih.gov/pubmed/30715276 http://dx.doi.org/10.1093/database/baz003 |
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