Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets

BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. Here, we aimed to identify in colon loss of FOXO3-dependent cellular and molecular changes that facilitate inflammation-mediated t...

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Detalles Bibliográficos
Autores principales: Penrose, Harrison M., Cable, Chloe, Heller, Sandra, Ungerleider, Nathan, Nakhoul, Hani, Baddoo, Melody, Hartono, Alifiani B., Lee, Sean B., Burow, Matthew E., Flemington, Erik F., Crawford, Susan E., Savkovic, Suzana D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360252/
https://www.ncbi.nlm.nih.gov/pubmed/30718226
http://dx.doi.org/10.1016/j.jcmgh.2018.10.003

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