Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

BACKGROUND: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplica...

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Detalles Bibliográficos
Autores principales: Adjei, George O., Amponsah, Seth K., Goka, Bamenla Q., Enweronu-Laryea, Christabel, Renner, Lorna, Sulley, Abdul Malik, Alifrangis, Michael, Kurtzhals, Jorgen A.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360331/
https://www.ncbi.nlm.nih.gov/pubmed/30766619
http://dx.doi.org/10.1016/j.curtheres.2019.01.005

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