Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1

Pancreatic stellate cells (PSCs), a key component of the tumor microenvironment, contribute to tumor invasion, metastasis, and chemoresistance. Osteopontin (OPN), a phosphorylated glycoprotein, is overexpressed in pancreatic cancer. However, OPN expression in PSCs and its potential roles in tumor–st...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Junyu, Li, Jie, Sun, Liankang, Qin, Tao, Xiao, Ying, Chen, Ke, Qian, Weikun, Duan, Wanxing, Lei, Jianjun, Ma, Jiguang, Ma, Qingyong, Han, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360359/
https://www.ncbi.nlm.nih.gov/pubmed/30367545
http://dx.doi.org/10.1002/1878-0261.12399

Ejemplares similares

Ejemplares similares