SIRT5‐mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer

Lactate dehydrogenase B (LDHB) is a glycolytic enzyme that catalyses the conversion of lactate and NAD (+) to pyruvate, NADH and H(+). Protons (H(+)) generated by LDHB promote lysosomal acidification and autophagy in cancer, but how this role is regulated has not been defined. In this study, we iden...

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Detalles Bibliográficos
Autores principales: Shi, Liang, Yan, Hui, An, Shuxian, Shen, Mengqin, Jia, Wenzhi, Zhang, Ruixue, Zhao, Li, Huang, Gang, Liu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360364/
https://www.ncbi.nlm.nih.gov/pubmed/30443978
http://dx.doi.org/10.1002/1878-0261.12408

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