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Lung adenocarcinoma and anti‐transcriptional intermediary factor 1‐gamma positive dermatomyositis complicated with spontaneous oesophageal rupture
A 58‐year‐old man presented with a two‐month history of facial erythema and dry cough. Physical examination revealed typical cutaneous manifestations of dermatomyositis (DM), including heliotrope rash and shawl sign. A chest X‐ray revealed a 4‐cm mass in the right middle lung. After bronchoscopy and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360367/ https://www.ncbi.nlm.nih.gov/pubmed/30766682 http://dx.doi.org/10.1002/rcr2.403 |
Sumario: | A 58‐year‐old man presented with a two‐month history of facial erythema and dry cough. Physical examination revealed typical cutaneous manifestations of dermatomyositis (DM), including heliotrope rash and shawl sign. A chest X‐ray revealed a 4‐cm mass in the right middle lung. After bronchoscopy and investigation of auto‐antibodies, he was diagnosed with co‐occurring transcriptional intermediary factor 1‐gamma (TIF1‐γ) positive DM and lung adenocarcinoma. He was administered oral prednisolone for subsequent muscle weakness, but developed TIF1‐γ positive DM‐associated oropharyngeal dysphagia complicated by spontaneous oesophageal rupture and died from progression of chemoresistant lung cancer. |
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