Cargando…
An EGFR‐targeting antibody–drug conjugate LR004‐VC‐MMAE: potential in esophageal squamous cell carcinoma and other malignancies
Epidermal growth factor receptor (EGFR) is a rational target for cancer therapy, because its overexpression plays an important oncogenic role in a variety of solid tumors; however, EGFR‐targeted antibody–drug conjugate (ADC) therapy for esophageal squamous cell carcinoma (ESCC) is exceedingly rare....
Autores principales: | Hu, Xin‐yue, Wang, Rong, Jin, Jie, Liu, Xiu‐jun, Cui, A‐long, Sun, Lian‐qi, Li, Yan‐ping, Li, Yi, Wang, Yu‐cheng, Zhen, Yong‐su, Miao, Qing‐fang, Li, Zhuo‐rong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360372/ https://www.ncbi.nlm.nih.gov/pubmed/30372581 http://dx.doi.org/10.1002/1878-0261.12400 |
Ejemplares similares
-
Bivalent EGFR-Targeting DARPin-MMAE Conjugates
por: Karsten, Lennard, et al.
Publicado: (2022) -
Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies
por: Li, Chunze, et al.
Publicado: (2019) -
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability
por: Yi, Ce, et al.
Publicado: (2023) -
Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy
por: Wang, Yanming, et al.
Publicado: (2019) -
Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera
por: Pei, Min, et al.
Publicado: (2022)