The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine

While HIV-1 subtype B has caused a large epidemic in the Western world, its transmission in Ukraine remains poorly understood. We assessed the genetic diversity of HIV-1 subtype B viruses circulating in Ukraine, characterized the transmission group structure, and estimated key evolutionary and epide...

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Autores principales: Vasylyeva, Tetyana I., Liulchuk, Mariia, du Plessis, Louis, Fearnhill, Esther, Zadorozhna, Victoriia, Babii, Nataliia, Scherbinska, Alla, Novitsky, Vladimir, Pybus, Oliver G., Faria, Nuno R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360399/
https://www.ncbi.nlm.nih.gov/pubmed/30430838
http://dx.doi.org/10.1089/aid.2018.0167
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author Vasylyeva, Tetyana I.
Liulchuk, Mariia
du Plessis, Louis
Fearnhill, Esther
Zadorozhna, Victoriia
Babii, Nataliia
Scherbinska, Alla
Novitsky, Vladimir
Pybus, Oliver G.
Faria, Nuno R.
author_facet Vasylyeva, Tetyana I.
Liulchuk, Mariia
du Plessis, Louis
Fearnhill, Esther
Zadorozhna, Victoriia
Babii, Nataliia
Scherbinska, Alla
Novitsky, Vladimir
Pybus, Oliver G.
Faria, Nuno R.
author_sort Vasylyeva, Tetyana I.
collection PubMed
description While HIV-1 subtype B has caused a large epidemic in the Western world, its transmission in Ukraine remains poorly understood. We assessed the genetic diversity of HIV-1 subtype B viruses circulating in Ukraine, characterized the transmission group structure, and estimated key evolutionary and epidemiological parameters. We analyzed 120 HIV-1 subtype B pol sequences (including 46 newly generated) sampled from patients residing in 11 regions of Ukraine between 2002 and 2017. Phylogenies were estimated using maximum likelihood and Bayesian phylogenetic methods. A Bayesian molecular clock coalescent analysis was used to estimate effective population size dynamics and date the most recent common ancestors of identified clades. A phylodynamic birth–death model was used to estimate the effective reproductive number (R(e)) of these clades. We identified two phylogenetically distinct predominantly Ukrainian (≥75%) clades of HIV-1 subtype B. We found no significant transmission group structure for either clade, suggesting frequent mixing among transmission groups. The estimated dates of origin of both subtype B clades were around early 1970s, similar to the introduction of HIV-1 subtype A into Ukraine. R(e) was estimated to be 1.42 [95% highest posterior density (HPD) 1.26–1.56] for Clade 1 and 1.69 (95% HPD 1.49–1.84) for Clade 2. Evidently, the subtype B epidemic in the country is no longer concentrated in specific geographical regions or transmission groups. The study results highlight the necessity for strengthening preventive and monitoring efforts to reduce the further spread of HIV-1 subtype B.
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spelling pubmed-63603992019-02-04 The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine Vasylyeva, Tetyana I. Liulchuk, Mariia du Plessis, Louis Fearnhill, Esther Zadorozhna, Victoriia Babii, Nataliia Scherbinska, Alla Novitsky, Vladimir Pybus, Oliver G. Faria, Nuno R. AIDS Res Hum Retroviruses Epidemiology While HIV-1 subtype B has caused a large epidemic in the Western world, its transmission in Ukraine remains poorly understood. We assessed the genetic diversity of HIV-1 subtype B viruses circulating in Ukraine, characterized the transmission group structure, and estimated key evolutionary and epidemiological parameters. We analyzed 120 HIV-1 subtype B pol sequences (including 46 newly generated) sampled from patients residing in 11 regions of Ukraine between 2002 and 2017. Phylogenies were estimated using maximum likelihood and Bayesian phylogenetic methods. A Bayesian molecular clock coalescent analysis was used to estimate effective population size dynamics and date the most recent common ancestors of identified clades. A phylodynamic birth–death model was used to estimate the effective reproductive number (R(e)) of these clades. We identified two phylogenetically distinct predominantly Ukrainian (≥75%) clades of HIV-1 subtype B. We found no significant transmission group structure for either clade, suggesting frequent mixing among transmission groups. The estimated dates of origin of both subtype B clades were around early 1970s, similar to the introduction of HIV-1 subtype A into Ukraine. R(e) was estimated to be 1.42 [95% highest posterior density (HPD) 1.26–1.56] for Clade 1 and 1.69 (95% HPD 1.49–1.84) for Clade 2. Evidently, the subtype B epidemic in the country is no longer concentrated in specific geographical regions or transmission groups. The study results highlight the necessity for strengthening preventive and monitoring efforts to reduce the further spread of HIV-1 subtype B. Mary Ann Liebert, Inc., publishers 2019-02-01 2019-01-31 /pmc/articles/PMC6360399/ /pubmed/30430838 http://dx.doi.org/10.1089/aid.2018.0167 Text en © Tetyana I. Vasylyeva et al. 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Epidemiology
Vasylyeva, Tetyana I.
Liulchuk, Mariia
du Plessis, Louis
Fearnhill, Esther
Zadorozhna, Victoriia
Babii, Nataliia
Scherbinska, Alla
Novitsky, Vladimir
Pybus, Oliver G.
Faria, Nuno R.
The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title_full The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title_fullStr The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title_full_unstemmed The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title_short The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
title_sort changing epidemiological profile of hiv-1 subtype b epidemic in ukraine
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360399/
https://www.ncbi.nlm.nih.gov/pubmed/30430838
http://dx.doi.org/10.1089/aid.2018.0167
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