Cargando…

TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways

Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers. TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of Th9 cells and antitumor immunity. However, the role of TNF-α, the prototype of the TNF superfamily cytokines, in Th9 cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Yuxue, Chen, Jintong, Bi, Enguang, Zhao, Yinghua, Qin, Tianxue, Wang, Yiming, Wang, Alison, Gao, Sujun, Yi, Qing, Wang, Siqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360681/ https://www.ncbi.nlm.nih.gov/pubmed/30717817 http://dx.doi.org/10.1186/s40425-018-0494-8

Ejemplares similares

TNF-a Is a Potent Stimulator of Tc9-Cell Differentiation
por: Yang, Siyu, et al.
Publicado: (2020)

Interleukin-33 Contributes to the Induction of Th9 Cells and Antitumor Efficacy by Dectin-1-Activated Dendritic Cells
por: Chen, Jintong, et al.
Publicado: (2018)

Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1
por: Zhu, Xiaoqing, et al.
Publicado: (2017)

IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy
por: Chen, Jintong, et al.
Publicado: (2023)

Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells
por: Zhao, Yinghua, et al.
Publicado: (2016)

Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches
por: Saddala, Madhu Sudhana, et al.
Publicado: (2019)

TNF-α Affects Signature Cytokines of Th1 and Th17 T Cell Subsets through Differential Actions on TNFR1 and TNFR2
por: Pesce, Bárbara, et al.
Publicado: (2022)

Preclinical and clinical aspects of TNF-α and its receptors TNFR1 and TNFR2 in breast cancer
por: Martínez-Reza, Isela, et al.
Publicado: (2017)

Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4(+)Foxp3(+) induced Treg cells in vitro and in vivo periphery in autoimmune diseases
por: Yang, Sujuan, et al.
Publicado: (2019)

YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling
por: Hessman, Christopher L., et al.
Publicado: (2020)

Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections
por: Ruiz, Andy, et al.
Publicado: (2021)

The effects of TNF‐α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer
por: Qu, Yang, et al.
Publicado: (2021)

TNFR/TNF-α signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis
por: Qian, Qing-Zeng, et al.
Publicado: (2017)

Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis
por: Gibellini, Lara, et al.
Publicado: (2016)

Editorial: Targeting TNF/TNFR signaling pathways
por: Pan, Liqiang, et al.
Publicado: (2023)

TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
por: Townsend, Jeremy R., et al.
Publicado: (2015)

Retinal degeneration in experimental coronavirus retinopathy (ECOR) is associated with increased TNF-α, soluble TNFR2 and altered TNF-α signaling
por: Hooper, Laura C., et al.
Publicado: (2005)

Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy
por: Aita, Ada, et al.
Publicado: (2018)

The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
por: Khan, Abrar Ul Haq, et al.
Publicado: (2023)

Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy
por: Uysal, Husnu, et al.
Publicado: (2018)

Cholesterol negatively regulates IL-9–producing CD8(+) T cell differentiation and antitumor activity
por: Ma, Xingzhe, et al.
Publicado: (2018)

TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
por: Bruggeman, Leslie A., et al.
Publicado: (2011)

The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response
por: Moatti, Audrey, et al.
Publicado: (2021)

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2022)

IL-9/STAT3/fatty acid oxidation–mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity
por: Xiao, Liuling, et al.
Publicado: (2022)

Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma
por: Tomolonis, Julie A, et al.
Publicado: (2023)

Potential regulatory mechanism of TNF-α/TNFR1/ANXA1 in glioma cells and its role in glioma cell proliferation
por: Zhu, Xiaotian, et al.
Publicado: (2022)

Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures
por: Steelman, Andrew J, et al.
Publicado: (2011)

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function
por: Beldi, Ghada, et al.
Publicado: (2020)

TNFα‐induced abnormal activation of TNFR/NF‐κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion
por: Wen, Yuting, et al.
Publicado: (2022)

TNF-α Autocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-α Receptors Support the Concept of Selective TNFR1 Blockade In Vivo
por: Gane, Jennie M., et al.
Publicado: (2016)

TNFR1-d2 carrying the p.(Thr79Met) pathogenic variant is a potential novel actor of TNFα/TNFR1 signalling regulation in the pathophysiology of TRAPS
por: Rittore, Cécile, et al.
Publicado: (2021)

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis
por: Yu, Hanjie, et al.
Publicado: (2022)

Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
por: McMillan, David, et al.
Publicado: (2021)

Polymorphic Variants of TNFR2 Gene in Schizophrenia and Its Interaction with -308G/A TNF-α Gene Polymorphism
por: Suchanek-Raif, Renata, et al.
Publicado: (2018)

TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
por: Cousins, Matthew M., et al.
Publicado: (2020)

Critical role of TNF-alpha-TNFR1 signaling in intracranial aneurysm formation
por: Aoki, Tomohiro, et al.
Publicado: (2014)

TNF-TNFR1 Signaling Enhances the Protection Against Neospora caninum Infection
por: Ferreira França, Flávia Batista, et al.
Publicado: (2022)

A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity
por: Vargas, Juan Gamboa, et al.
Publicado: (2022)

Contributing role of TNF, IL-10, sTNFR1 and TNF gene polymorphisms in disease severity of leptospirosis
por: Nisansala, Thilini, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rsejbee48efgs38uagr49berpm