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PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27(Kip1) axis

BACKGROUND: Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression...

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Detalles Bibliográficos
Autores principales:	Tuo, Lin, Xiang, Jin, Pan, Xuanming, Hu, Jieli, Tang, Hua, Liang, Li, Xia, Jie, Hu, Yuan, Zhang, Wenlu, Huang, Ailong, Wang, Kai, Tang, Ni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360696/ https://www.ncbi.nlm.nih.gov/pubmed/30717766 http://dx.doi.org/10.1186/s13046-019-1029-y

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