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Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors

BACKGROUND: Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited, novel therapeutic approaches are desperately needed. Here the potential of si...

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Detalles Bibliográficos
Autores principales:	Wang, Zhihai, Zuo, Wenqi, Zeng, Quan, Qian, Yi, Li, Yanshi, Liu, Chuan, Wang, Jue, Zhong, Shixun, Bu, Youquan, Hu, Guohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360700/ https://www.ncbi.nlm.nih.gov/pubmed/30717758 http://dx.doi.org/10.1186/s12929-019-0507-z

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