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Ameloblastoma with distinctive granular cell pattern: an 8 case study

Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload cau...

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Autores principales: Cadavid, Ana Maria Hoyos, Teshima, Tathyane Harumi Nakajima, Pinto, Clóvis Antônio Lopes, Camillo, Cláudia Malheiros Coutinho, Lourenço, Silvia Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360828/
https://www.ncbi.nlm.nih.gov/pubmed/30775327
http://dx.doi.org/10.4322/acr.2018.052
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author Cadavid, Ana Maria Hoyos
Teshima, Tathyane Harumi Nakajima
Pinto, Clóvis Antônio Lopes
Camillo, Cláudia Malheiros Coutinho
Lourenço, Silvia Vanessa
author_facet Cadavid, Ana Maria Hoyos
Teshima, Tathyane Harumi Nakajima
Pinto, Clóvis Antônio Lopes
Camillo, Cláudia Malheiros Coutinho
Lourenço, Silvia Vanessa
author_sort Cadavid, Ana Maria Hoyos
collection PubMed
description Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.
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spelling pubmed-63608282019-02-15 Ameloblastoma with distinctive granular cell pattern: an 8 case study Cadavid, Ana Maria Hoyos Teshima, Tathyane Harumi Nakajima Pinto, Clóvis Antônio Lopes Camillo, Cláudia Malheiros Coutinho Lourenço, Silvia Vanessa Autops Case Rep Article / Clinical Case Report Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018-10-09 /pmc/articles/PMC6360828/ /pubmed/30775327 http://dx.doi.org/10.4322/acr.2018.052 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2018. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited.
spellingShingle Article / Clinical Case Report
Cadavid, Ana Maria Hoyos
Teshima, Tathyane Harumi Nakajima
Pinto, Clóvis Antônio Lopes
Camillo, Cláudia Malheiros Coutinho
Lourenço, Silvia Vanessa
Ameloblastoma with distinctive granular cell pattern: an 8 case study
title Ameloblastoma with distinctive granular cell pattern: an 8 case study
title_full Ameloblastoma with distinctive granular cell pattern: an 8 case study
title_fullStr Ameloblastoma with distinctive granular cell pattern: an 8 case study
title_full_unstemmed Ameloblastoma with distinctive granular cell pattern: an 8 case study
title_short Ameloblastoma with distinctive granular cell pattern: an 8 case study
title_sort ameloblastoma with distinctive granular cell pattern: an 8 case study
topic Article / Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360828/
https://www.ncbi.nlm.nih.gov/pubmed/30775327
http://dx.doi.org/10.4322/acr.2018.052
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