Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...

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Autores principales: Fidai, Shiraz S., Sharma, Aarti E., Johnson, Daniel N., Segal, Jeremy P., Lastra, Ricardo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018
Materias:
Article / Autopsy Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360833/
https://www.ncbi.nlm.nih.gov/pubmed/30775324
http://dx.doi.org/10.4322/acr.2018.049
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author Fidai, Shiraz S.
Sharma, Aarti E.
Johnson, Daniel N.
Segal, Jeremy P.
Lastra, Ricardo R.
author_facet Fidai, Shiraz S.
Sharma, Aarti E.
Johnson, Daniel N.
Segal, Jeremy P.
Lastra, Ricardo R.
author_sort Fidai, Shiraz S.
collection PubMed
description 5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the population demonstrate complete DPD deficiency, translating to extreme toxicity of 5-FU. Here we present a case of a patient who had a fatal outcome after treatment with 5-FU who was found to have an unknown DPD deficiency discovered at autopsy.
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spelling pubmed-63608332019-02-15 Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity Fidai, Shiraz S. Sharma, Aarti E. Johnson, Daniel N. Segal, Jeremy P. Lastra, Ricardo R. Autops Case Rep Article / Autopsy Case Report 5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the population demonstrate complete DPD deficiency, translating to extreme toxicity of 5-FU. Here we present a case of a patient who had a fatal outcome after treatment with 5-FU who was found to have an unknown DPD deficiency discovered at autopsy. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018-11-30 /pmc/articles/PMC6360833/ /pubmed/30775324 http://dx.doi.org/10.4322/acr.2018.049 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2018. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited.
spellingShingle Article / Autopsy Case Report
Fidai, Shiraz S.
Sharma, Aarti E.
Johnson, Daniel N.
Segal, Jeremy P.
Lastra, Ricardo R.
Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title_full Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title_fullStr Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title_full_unstemmed Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title_short Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity
title_sort dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-fluorouracil toxicity
topic Article / Autopsy Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360833/
https://www.ncbi.nlm.nih.gov/pubmed/30775324
http://dx.doi.org/10.4322/acr.2018.049
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