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Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the pop...

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Detalles Bibliográficos
Autores principales:	Fidai, Shiraz S., Sharma, Aarti E., Johnson, Daniel N., Segal, Jeremy P., Lastra, Ricardo R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018
Materias:	Article / Autopsy Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360833/ https://www.ncbi.nlm.nih.gov/pubmed/30775324 http://dx.doi.org/10.4322/acr.2018.049

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