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Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims

BACKGROUND: Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before–after study was to investigat...

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Autores principales: Rahbar, Ali R., Safavi, Eisa, Rooholamini, Maryam, Jaafari, Fateme, Darvishi, Sadegh, Rahbar, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360844/
https://www.ncbi.nlm.nih.gov/pubmed/30774841
http://dx.doi.org/10.4103/ijpvm.IJPVM_252_17
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author Rahbar, Ali R.
Safavi, Eisa
Rooholamini, Maryam
Jaafari, Fateme
Darvishi, Sadegh
Rahbar, Amin
author_facet Rahbar, Ali R.
Safavi, Eisa
Rooholamini, Maryam
Jaafari, Fateme
Darvishi, Sadegh
Rahbar, Amin
author_sort Rahbar, Ali R.
collection PubMed
description BACKGROUND: Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before–after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals. METHODS: In all, 34 men age 16–64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan. A sample of blood was drawn from the contributors before and after Ramadan, and plasma IGF-1, IL-2, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined. To identify differences between the initial and final values of test results of the study for plasma IGF-1, IL-2, and lipid parameters, we used paired sample T-test. RESULTS: Paired sample T-test illustrated a significant decrease in IGF-1 and IL-2 levels after Ramadan fasting compared to before Ramadan. The concentration of TG, cholesterol, and LDL-C levels underwent significant decreases over the period of the study. HDL-C levels did not change significantly during the study. A significant decrease in weight, waist circumferences, calorie, carbohydrate, and fat intake were observed in participants during Ramadan fasting. CONCLUSIONS: It is concluded that fasting in Ramadan independent of anthropometric measures attenuates inflammation and is beneficiary to health.
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spelling pubmed-63608442019-02-17 Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims Rahbar, Ali R. Safavi, Eisa Rooholamini, Maryam Jaafari, Fateme Darvishi, Sadegh Rahbar, Amin Int J Prev Med Original Article BACKGROUND: Insulin-like growth factor-1 (IGF-1) and interleukin-2 (IL-2) play an essential role in pathophysiology of several chronic diseases. As a stressor, fasting in Ramadan may increase inflammatory markers such as IGF-1 and IL-2 in Muslims. The aim of this before–after study was to investigate the effects of fasting in Ramadan on IGF-1 and IL-2 levels in individuals. METHODS: In all, 34 men age 16–64 years were selected out of the overall number of individuals who were ready for fasting entirely throughout Ramadan. A sample of blood was drawn from the contributors before and after Ramadan, and plasma IGF-1, IL-2, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined. To identify differences between the initial and final values of test results of the study for plasma IGF-1, IL-2, and lipid parameters, we used paired sample T-test. RESULTS: Paired sample T-test illustrated a significant decrease in IGF-1 and IL-2 levels after Ramadan fasting compared to before Ramadan. The concentration of TG, cholesterol, and LDL-C levels underwent significant decreases over the period of the study. HDL-C levels did not change significantly during the study. A significant decrease in weight, waist circumferences, calorie, carbohydrate, and fat intake were observed in participants during Ramadan fasting. CONCLUSIONS: It is concluded that fasting in Ramadan independent of anthropometric measures attenuates inflammation and is beneficiary to health. Medknow Publications & Media Pvt Ltd 2019-01-15 /pmc/articles/PMC6360844/ /pubmed/30774841 http://dx.doi.org/10.4103/ijpvm.IJPVM_252_17 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Rahbar, Ali R.
Safavi, Eisa
Rooholamini, Maryam
Jaafari, Fateme
Darvishi, Sadegh
Rahbar, Amin
Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title_full Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title_fullStr Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title_full_unstemmed Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title_short Effects of Intermittent Fasting during Ramadan on Insulin-like Growth Factor-1, Interleukin 2, and Lipid Profile in Healthy Muslims
title_sort effects of intermittent fasting during ramadan on insulin-like growth factor-1, interleukin 2, and lipid profile in healthy muslims
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360844/
https://www.ncbi.nlm.nih.gov/pubmed/30774841
http://dx.doi.org/10.4103/ijpvm.IJPVM_252_17
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