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Desmoplastic melanoma: a rare variant with challenging diagnosis
Desmoplastic melanoma, a distinct and uncommon variant, is characterized as an invasive lesion with proliferation of fusiform melanocytes in the dermis and subcutaneous tissue, associated with varying patterns of desmoplasia. Neurotropism and neural differentiation may occur. The clinical presentati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360974/ https://www.ncbi.nlm.nih.gov/pubmed/30726469 http://dx.doi.org/10.1590/abd1806-4841.20197481 |
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author | Marques, Priscila Castelan Diniz, Lucia Martins Spelta, Karla Nogueira, Paulo Sergio Emerich |
author_facet | Marques, Priscila Castelan Diniz, Lucia Martins Spelta, Karla Nogueira, Paulo Sergio Emerich |
author_sort | Marques, Priscila Castelan |
collection | PubMed |
description | Desmoplastic melanoma, a distinct and uncommon variant, is characterized as an invasive lesion with proliferation of fusiform melanocytes in the dermis and subcutaneous tissue, associated with varying patterns of desmoplasia. Neurotropism and neural differentiation may occur. The clinical presentation is variable and nonspecific, easily confused with other fibrous neoplasms. The disease is locally aggressive and shows lower metastasis rates than other types of melanoma. Histopathology may be insufficient, requiring positive immunohistochemistry for S-100 protein and other antigens of melanocytic differentiation. Because desmoplastic melanoma represents a true clinical, dermoscopic, and histopathological diagnostic challenge, a case of invasive desmoplastic melanoma is reported, affecting a photoexposed area in an elderly woman after histological revisions and an initial diagnosis of fibroma. |
format | Online Article Text |
id | pubmed-6360974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-63609742019-02-11 Desmoplastic melanoma: a rare variant with challenging diagnosis Marques, Priscila Castelan Diniz, Lucia Martins Spelta, Karla Nogueira, Paulo Sergio Emerich An Bras Dermatol Case Report Desmoplastic melanoma, a distinct and uncommon variant, is characterized as an invasive lesion with proliferation of fusiform melanocytes in the dermis and subcutaneous tissue, associated with varying patterns of desmoplasia. Neurotropism and neural differentiation may occur. The clinical presentation is variable and nonspecific, easily confused with other fibrous neoplasms. The disease is locally aggressive and shows lower metastasis rates than other types of melanoma. Histopathology may be insufficient, requiring positive immunohistochemistry for S-100 protein and other antigens of melanocytic differentiation. Because desmoplastic melanoma represents a true clinical, dermoscopic, and histopathological diagnostic challenge, a case of invasive desmoplastic melanoma is reported, affecting a photoexposed area in an elderly woman after histological revisions and an initial diagnosis of fibroma. Sociedade Brasileira de Dermatologia 2019 /pmc/articles/PMC6360974/ /pubmed/30726469 http://dx.doi.org/10.1590/abd1806-4841.20197481 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Case Report Marques, Priscila Castelan Diniz, Lucia Martins Spelta, Karla Nogueira, Paulo Sergio Emerich Desmoplastic melanoma: a rare variant with challenging diagnosis |
title | Desmoplastic melanoma: a rare variant with challenging diagnosis |
title_full | Desmoplastic melanoma: a rare variant with challenging diagnosis |
title_fullStr | Desmoplastic melanoma: a rare variant with challenging diagnosis |
title_full_unstemmed | Desmoplastic melanoma: a rare variant with challenging diagnosis |
title_short | Desmoplastic melanoma: a rare variant with challenging diagnosis |
title_sort | desmoplastic melanoma: a rare variant with challenging diagnosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360974/ https://www.ncbi.nlm.nih.gov/pubmed/30726469 http://dx.doi.org/10.1590/abd1806-4841.20197481 |
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