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Health-related quality of life of patients with inflammatory bowel disease in Singapore
BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is associated with considerable impairment of patients’ health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients’ HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Wester...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association for the Study of Intestinal Diseases
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361019/ https://www.ncbi.nlm.nih.gov/pubmed/30419638 http://dx.doi.org/10.5217/ir.2018.00099 |
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author | Min Ho, Prisca Yue Hu, Wenjia Lee, Ying Yun Gao, Chuxi Tan, Yan Zhi Cheen, Hua Heng Wee, Hwee Lin Lim, Teong Guan Ong, Wan Chee |
author_facet | Min Ho, Prisca Yue Hu, Wenjia Lee, Ying Yun Gao, Chuxi Tan, Yan Zhi Cheen, Hua Heng Wee, Hwee Lin Lim, Teong Guan Ong, Wan Chee |
author_sort | Min Ho, Prisca Yue |
collection | PubMed |
description | BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is associated with considerable impairment of patients’ health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients’ HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants. METHODS: A prospective, cross-sectional study was conducted at Singapore General Hospital outpatient IBD Centre. The HRQoL of IBD patients was assessed using the short IBD questionnaire (SIBDQ), Short Form-36 physical and mental component summary (SF-36 PCS/MCS) and EuroQol 5-dimensions 3-levels (EQ-5D-3L) and visual analogue scale (VAS). Independent samples t-test was used to compare HRQoL between Crohn’s disease (CD) and ulcerative colitis (UC). Determinants of HRQoL were identified through multiple linear regression. RESULTS: A total of 195 IBD patients (103 UC, 92 CD) with a mean disease duration of 11.2 years were included. There was no significant difference in HRQoL between patients with UC and CD. Factors that significantly worsened HRQoL were presence of active disease (b=−6.293 [SIBDQ], −9.409 [PCS], −9.743 [MCS], −7.254 [VAS]), corticosteroids use (b=−7.392 [SIBDQ], −10.390 [PCS], −8.827 [MCS]), poor medication adherence (b=−4.049 [SIBDQ], −1.320 [MCS], −8.961 [VAS]), presence of extraintestinal manifestations (b=−13.381 [PCS]), comorbidities (b=−4.531 [PCS]), non-employment (b=−9.738 [MCS], −0.104 [EQ-5D-3L]) and public housing (b=−8.070 [PCS], −9.207 [VAS]). CONCLUSIONS: The HRQoL is impaired in this Asian cohort of IBD. The magnitude of HRQoL impairment was similar in UC and CD. Clinical characteristics were better determinants of patients’ HRQoL than socio-demographic factors. Recognizing the factors that impact patients’ HRQoL would improve the holistic management of IBD patients. |
format | Online Article Text |
id | pubmed-6361019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Association for the Study of Intestinal Diseases |
record_format | MEDLINE/PubMed |
spelling | pubmed-63610192019-02-14 Health-related quality of life of patients with inflammatory bowel disease in Singapore Min Ho, Prisca Yue Hu, Wenjia Lee, Ying Yun Gao, Chuxi Tan, Yan Zhi Cheen, Hua Heng Wee, Hwee Lin Lim, Teong Guan Ong, Wan Chee Intest Res Original Article BACKGROUND/AIMS: Inflammatory bowel disease (IBD) is associated with considerable impairment of patients’ health-related quality of life (HRQoL). Knowledge of factors that significantly affect IBD patients’ HRQoL can contribute to better patient care. However, the HRQoL of IBD patients in non-Western countries are limited. Hence, we assessed the HRQoL of Singaporean IBD patients and identified its determinants. METHODS: A prospective, cross-sectional study was conducted at Singapore General Hospital outpatient IBD Centre. The HRQoL of IBD patients was assessed using the short IBD questionnaire (SIBDQ), Short Form-36 physical and mental component summary (SF-36 PCS/MCS) and EuroQol 5-dimensions 3-levels (EQ-5D-3L) and visual analogue scale (VAS). Independent samples t-test was used to compare HRQoL between Crohn’s disease (CD) and ulcerative colitis (UC). Determinants of HRQoL were identified through multiple linear regression. RESULTS: A total of 195 IBD patients (103 UC, 92 CD) with a mean disease duration of 11.2 years were included. There was no significant difference in HRQoL between patients with UC and CD. Factors that significantly worsened HRQoL were presence of active disease (b=−6.293 [SIBDQ], −9.409 [PCS], −9.743 [MCS], −7.254 [VAS]), corticosteroids use (b=−7.392 [SIBDQ], −10.390 [PCS], −8.827 [MCS]), poor medication adherence (b=−4.049 [SIBDQ], −1.320 [MCS], −8.961 [VAS]), presence of extraintestinal manifestations (b=−13.381 [PCS]), comorbidities (b=−4.531 [PCS]), non-employment (b=−9.738 [MCS], −0.104 [EQ-5D-3L]) and public housing (b=−8.070 [PCS], −9.207 [VAS]). CONCLUSIONS: The HRQoL is impaired in this Asian cohort of IBD. The magnitude of HRQoL impairment was similar in UC and CD. Clinical characteristics were better determinants of patients’ HRQoL than socio-demographic factors. Recognizing the factors that impact patients’ HRQoL would improve the holistic management of IBD patients. Korean Association for the Study of Intestinal Diseases 2019-01 2018-11-12 /pmc/articles/PMC6361019/ /pubmed/30419638 http://dx.doi.org/10.5217/ir.2018.00099 Text en © Copyright 2019. Korean Association for the Study of Intestinal Diseases. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Min Ho, Prisca Yue Hu, Wenjia Lee, Ying Yun Gao, Chuxi Tan, Yan Zhi Cheen, Hua Heng Wee, Hwee Lin Lim, Teong Guan Ong, Wan Chee Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title | Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title_full | Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title_fullStr | Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title_full_unstemmed | Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title_short | Health-related quality of life of patients with inflammatory bowel disease in Singapore |
title_sort | health-related quality of life of patients with inflammatory bowel disease in singapore |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361019/ https://www.ncbi.nlm.nih.gov/pubmed/30419638 http://dx.doi.org/10.5217/ir.2018.00099 |
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