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Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression

OBJECTIVE: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of...

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Autores principales: Çelik, Cemil, Bolu, Abdullah, Öznur, Taner, Aydın, Mehmet Sinan, Tokgöz, Yusuf, Uzun, Özcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361038/
https://www.ncbi.nlm.nih.gov/pubmed/30690942
http://dx.doi.org/10.9758/cpn.2019.17.1.74
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author Çelik, Cemil
Bolu, Abdullah
Öznur, Taner
Aydın, Mehmet Sinan
Tokgöz, Yusuf
Uzun, Özcan
author_facet Çelik, Cemil
Bolu, Abdullah
Öznur, Taner
Aydın, Mehmet Sinan
Tokgöz, Yusuf
Uzun, Özcan
author_sort Çelik, Cemil
collection PubMed
description OBJECTIVE: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression. METHODS: Twenty-nine patients with treatment resistant major depression and thirty healthy volunteers were included in the study. Pre- and post-ECT levels of myostatine were compared; also this results were compared to healthy controls. RESULTS: For 29 patients with treatment-resistant major depression, the pre-treatment mean myostatin level was 0.95±0.32 ng/ml and post-therapy myostatin level was 11.05±6.97 ng/ml. As a result of this study, it is found that ECT affects serum myostatin levels to a significant degree (t=4.17, p<0.05). It is also found that there was a significant relation between serum myostatin levels and depression scores (r=0.392, p<0.05). CONCLUSION: With the present study and similar ones, it can be understood that how ECT achieves its effectiveness biologically.
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spelling pubmed-63610382019-02-14 Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression Çelik, Cemil Bolu, Abdullah Öznur, Taner Aydın, Mehmet Sinan Tokgöz, Yusuf Uzun, Özcan Clin Psychopharmacol Neurosci Original Article OBJECTIVE: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression. METHODS: Twenty-nine patients with treatment resistant major depression and thirty healthy volunteers were included in the study. Pre- and post-ECT levels of myostatine were compared; also this results were compared to healthy controls. RESULTS: For 29 patients with treatment-resistant major depression, the pre-treatment mean myostatin level was 0.95±0.32 ng/ml and post-therapy myostatin level was 11.05±6.97 ng/ml. As a result of this study, it is found that ECT affects serum myostatin levels to a significant degree (t=4.17, p<0.05). It is also found that there was a significant relation between serum myostatin levels and depression scores (r=0.392, p<0.05). CONCLUSION: With the present study and similar ones, it can be understood that how ECT achieves its effectiveness biologically. Korean College of Neuropsychopharmacology 2019-02 2019-02-28 /pmc/articles/PMC6361038/ /pubmed/30690942 http://dx.doi.org/10.9758/cpn.2019.17.1.74 Text en Copyright © 2019, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Çelik, Cemil
Bolu, Abdullah
Öznur, Taner
Aydın, Mehmet Sinan
Tokgöz, Yusuf
Uzun, Özcan
Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title_full Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title_fullStr Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title_full_unstemmed Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title_short Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression
title_sort changes in pre- and post-electroconvulsive therapy serum myostatin levels in patients with treatment resistant depression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361038/
https://www.ncbi.nlm.nih.gov/pubmed/30690942
http://dx.doi.org/10.9758/cpn.2019.17.1.74
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