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Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder
OBJECTIVE: In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs. METHODS: A total of 70 ADHD patients and 69 healthy controls were enrolled in our study. During the di...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean College of Neuropsychopharmacology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361043/ https://www.ncbi.nlm.nih.gov/pubmed/30690945 http://dx.doi.org/10.9758/cpn.2019.17.1.105 |
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author | Yazici, Kemal Utku Yazici, Ipek Percinel Ustundag, Bilal |
author_facet | Yazici, Kemal Utku Yazici, Ipek Percinel Ustundag, Bilal |
author_sort | Yazici, Kemal Utku |
collection | PubMed |
description | OBJECTIVE: In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs. METHODS: A total of 70 ADHD patients and 69 healthy controls were enrolled in our study. During the diagnosis, the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version were applied. The sociodemographic data form, Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale, and Conners’ Rating Scales-Revised: Long Form were used for the clinical evaluation. Serum hepcidin levels were measured and compared between the groups. RESULTS: No significant difference between the groups in terms of age (p=0.533) and gender (p=0.397) was determined. In addition, the groups did not differ significantly for the other sociodemographic variables recorded. Serum hepcidin levels were found to be significantly higher in the patients with ADHD than healthy controls (p=0.019). CONCLUSION: To the best of our knowledge, this study is the first to evaluate the total serum hepcidin levels in ADHD patients. Our study findings may suggest that high levels of hepcidin may cause iron dysregulation in ADHD patients. However, further studies are required to establish a definite conclusion. |
format | Online Article Text |
id | pubmed-6361043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean College of Neuropsychopharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63610432019-02-14 Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder Yazici, Kemal Utku Yazici, Ipek Percinel Ustundag, Bilal Clin Psychopharmacol Neurosci Original Article OBJECTIVE: In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs. METHODS: A total of 70 ADHD patients and 69 healthy controls were enrolled in our study. During the diagnosis, the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version were applied. The sociodemographic data form, Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale, and Conners’ Rating Scales-Revised: Long Form were used for the clinical evaluation. Serum hepcidin levels were measured and compared between the groups. RESULTS: No significant difference between the groups in terms of age (p=0.533) and gender (p=0.397) was determined. In addition, the groups did not differ significantly for the other sociodemographic variables recorded. Serum hepcidin levels were found to be significantly higher in the patients with ADHD than healthy controls (p=0.019). CONCLUSION: To the best of our knowledge, this study is the first to evaluate the total serum hepcidin levels in ADHD patients. Our study findings may suggest that high levels of hepcidin may cause iron dysregulation in ADHD patients. However, further studies are required to establish a definite conclusion. Korean College of Neuropsychopharmacology 2019-02 2019-02-28 /pmc/articles/PMC6361043/ /pubmed/30690945 http://dx.doi.org/10.9758/cpn.2019.17.1.105 Text en Copyright © 2019, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yazici, Kemal Utku Yazici, Ipek Percinel Ustundag, Bilal Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title | Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title_full | Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title_fullStr | Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title_full_unstemmed | Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title_short | Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder |
title_sort | increased serum hepcidin levels in children and adolescents with attention deficit hyperactivity disorder |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361043/ https://www.ncbi.nlm.nih.gov/pubmed/30690945 http://dx.doi.org/10.9758/cpn.2019.17.1.105 |
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