SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models

Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here, we show that endogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Marinello, Martina, Werner, Andreas, Giannone, Mariagiovanna, Tahiri, Khadija, Alves, Sandro, Tesson, Christelle, den Dunnen, Wilfred, Seeler, Jacob-S., Brice, Alexis, Sittler, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361149/
https://www.ncbi.nlm.nih.gov/pubmed/30559154
http://dx.doi.org/10.1242/dmm.036145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361149/
https://www.ncbi.nlm.nih.gov/pubmed/30559154
http://dx.doi.org/10.1242/dmm.036145

Ejemplares similares