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SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models

Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here, we show that endogen...

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Detalles Bibliográficos
Autores principales:	Marinello, Martina, Werner, Andreas, Giannone, Mariagiovanna, Tahiri, Khadija, Alves, Sandro, Tesson, Christelle, den Dunnen, Wilfred, Seeler, Jacob-S., Brice, Alexis, Sittler, Annie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361149/ https://www.ncbi.nlm.nih.gov/pubmed/30559154 http://dx.doi.org/10.1242/dmm.036145

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