Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

Chorea-acanthocytosis (ChAc) is a rare neurodegenerative disease associated with mutations in the human VPS13A gene. The mechanism of ChAc pathogenesis is unclear. A simple yeast model was used to investigate the function of the single yeast VSP13 orthologue, Vps13. Vps13, like human VPS13A, is invo...

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Detalles Bibliográficos
Autores principales: Soczewka, Piotr, Kolakowski, Damian, Smaczynska-de Rooij, Iwona, Rzepnikowska, Weronika, Ayscough, Kathryn R., Kaminska, Joanna, Zoladek, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361151/
https://www.ncbi.nlm.nih.gov/pubmed/30635263
http://dx.doi.org/10.1242/dmm.036830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361151/
https://www.ncbi.nlm.nih.gov/pubmed/30635263
http://dx.doi.org/10.1242/dmm.036830

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