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Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine (DA) neurons, has been hypothesized to be broadly activated by aversive stimuli. However, this encoding pattern has only been demonstrated for a limited number of stimuli, and the RMTg influence on ventral tegmental...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361585/ https://www.ncbi.nlm.nih.gov/pubmed/30667358 http://dx.doi.org/10.7554/eLife.41542 |
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author | Li, Hao Pullmann, Dominika Cho, Jennifer Y Eid, Maya Jhou, Thomas C |
author_facet | Li, Hao Pullmann, Dominika Cho, Jennifer Y Eid, Maya Jhou, Thomas C |
author_sort | Li, Hao |
collection | PubMed |
description | The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine (DA) neurons, has been hypothesized to be broadly activated by aversive stimuli. However, this encoding pattern has only been demonstrated for a limited number of stimuli, and the RMTg influence on ventral tegmental (VTA) responses to aversive stimuli is untested. Here, we found that RMTg neurons are broadly excited by aversive stimuli of different sensory modalities and inhibited by reward-related stimuli. These stimuli include visual, auditory, somatosensory and chemical aversive stimuli, as well as “opponent” motivational states induced by removal of sustained rewarding or aversive stimuli. These patterns are consistent with broad encoding of negative valence in a subset of RMTg neurons. We further found that valence-encoding RMTg neurons preferentially project to the DA-rich VTA versus other targets, and excitotoxic RMTg lesions greatly reduce aversive stimulus-induced inhibitions in VTA neurons, particularly putative DA neurons, while also impairing conditioned place aversion to multiple aversive stimuli. Together, our findings indicate a broad RMTg role in encoding aversion and driving VTA responses and behavior. |
format | Online Article Text |
id | pubmed-6361585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63615852019-02-06 Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing Li, Hao Pullmann, Dominika Cho, Jennifer Y Eid, Maya Jhou, Thomas C eLife Neuroscience The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine (DA) neurons, has been hypothesized to be broadly activated by aversive stimuli. However, this encoding pattern has only been demonstrated for a limited number of stimuli, and the RMTg influence on ventral tegmental (VTA) responses to aversive stimuli is untested. Here, we found that RMTg neurons are broadly excited by aversive stimuli of different sensory modalities and inhibited by reward-related stimuli. These stimuli include visual, auditory, somatosensory and chemical aversive stimuli, as well as “opponent” motivational states induced by removal of sustained rewarding or aversive stimuli. These patterns are consistent with broad encoding of negative valence in a subset of RMTg neurons. We further found that valence-encoding RMTg neurons preferentially project to the DA-rich VTA versus other targets, and excitotoxic RMTg lesions greatly reduce aversive stimulus-induced inhibitions in VTA neurons, particularly putative DA neurons, while also impairing conditioned place aversion to multiple aversive stimuli. Together, our findings indicate a broad RMTg role in encoding aversion and driving VTA responses and behavior. eLife Sciences Publications, Ltd 2019-01-22 /pmc/articles/PMC6361585/ /pubmed/30667358 http://dx.doi.org/10.7554/eLife.41542 Text en © 2019, Li et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Li, Hao Pullmann, Dominika Cho, Jennifer Y Eid, Maya Jhou, Thomas C Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title | Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title_full | Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title_fullStr | Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title_full_unstemmed | Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title_short | Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing |
title_sort | generality and opponency of rostromedial tegmental (rmtg) roles in valence processing |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361585/ https://www.ncbi.nlm.nih.gov/pubmed/30667358 http://dx.doi.org/10.7554/eLife.41542 |
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