Anti‐tumor effects of mAb against l‐type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes

l‐Type amino acid transporter 1 (LAT1) disulfide linked to CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In the present study, we developed novel anti‐LAT1 mAbs and showed internalization activity, inhibitory effects of amino acid uptake and ce...

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Detalles Bibliográficos
Autores principales: Ueda, Shiho, Hayashi, Hidemi, Miyamoto, Takako, Abe, Shinya, Hirai, Kana, Matsukura, Kanji, Yagi, Hideki, Hara, Yuta, Yoshida, Kinji, Okazaki, Shogo, Tamura, Masakazu, Abe, Yuki, Agatsuma, Toshinori, Niwa, Shin‐ichiro, Masuko, Kazue, Masuko, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361610/
https://www.ncbi.nlm.nih.gov/pubmed/30548114
http://dx.doi.org/10.1111/cas.13908

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