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Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring

In recent years, evidence has accumulated that non-Mendelian transgenerational inheritance of qualities acquired through experience is possible. In particular, it has been shown that raising rodents in a so-called enriched environment (EE) can not only modify the animals’ behavior and increase their...

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Autores principales: Kalogeraki, Evgenia, Yusifov, Rashad, Löwel, Siegrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361622/
https://www.ncbi.nlm.nih.gov/pubmed/30805555
http://dx.doi.org/10.1523/ENEURO.0252-18.2018
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author Kalogeraki, Evgenia
Yusifov, Rashad
Löwel, Siegrid
author_facet Kalogeraki, Evgenia
Yusifov, Rashad
Löwel, Siegrid
author_sort Kalogeraki, Evgenia
collection PubMed
description In recent years, evidence has accumulated that non-Mendelian transgenerational inheritance of qualities acquired through experience is possible. In particular, it has been shown that raising rodents in a so-called enriched environment (EE) can not only modify the animals’ behavior and increase their susceptibility to activity-dependent neuronal network changes, but also influences both behavior and neuronal plasticity of the non-enriched offspring. Here, we tested whether such a transgenerational transmission can also be observed in the primary visual cortex (V1) using ocular dominance (OD) plasticity after monocular deprivation (MD) as a paradigm. Whereas OD plasticity after 7 d of MD is absent in standard-cage (SC) raised mice beyond postnatal day (P)110, it is present lifelong in EE-raised mice. Using intrinsic signal optical imaging to visualize cortical activity, we confirm these previous observations and additionally show that OD plasticity is not only preserved in adult EE mice but also in their adult non-enriched offspring: mice born to enriched parents, but raised in SCs at least until P110 displayed similar OD shifts toward the open eye after 7 d of MD as age-matched EE-raised animals. Furthermore, testing the offspring of EE-female versus EE-males with SC-mating partners revealed that only pups of EE-females, but not of EE-males, preserved OD plasticity into adulthood, suggesting that the life experiences of the mother have a greater impact on the continued V1 plasticity of the offspring. The OD plasticity of the non-enriched pups of EE-mothers was, however, mechanistically different from that of non-enriched pups of EE-parents or EE mice.
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spelling pubmed-63616222019-02-25 Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring Kalogeraki, Evgenia Yusifov, Rashad Löwel, Siegrid eNeuro New Research In recent years, evidence has accumulated that non-Mendelian transgenerational inheritance of qualities acquired through experience is possible. In particular, it has been shown that raising rodents in a so-called enriched environment (EE) can not only modify the animals’ behavior and increase their susceptibility to activity-dependent neuronal network changes, but also influences both behavior and neuronal plasticity of the non-enriched offspring. Here, we tested whether such a transgenerational transmission can also be observed in the primary visual cortex (V1) using ocular dominance (OD) plasticity after monocular deprivation (MD) as a paradigm. Whereas OD plasticity after 7 d of MD is absent in standard-cage (SC) raised mice beyond postnatal day (P)110, it is present lifelong in EE-raised mice. Using intrinsic signal optical imaging to visualize cortical activity, we confirm these previous observations and additionally show that OD plasticity is not only preserved in adult EE mice but also in their adult non-enriched offspring: mice born to enriched parents, but raised in SCs at least until P110 displayed similar OD shifts toward the open eye after 7 d of MD as age-matched EE-raised animals. Furthermore, testing the offspring of EE-female versus EE-males with SC-mating partners revealed that only pups of EE-females, but not of EE-males, preserved OD plasticity into adulthood, suggesting that the life experiences of the mother have a greater impact on the continued V1 plasticity of the offspring. The OD plasticity of the non-enriched pups of EE-mothers was, however, mechanistically different from that of non-enriched pups of EE-parents or EE mice. Society for Neuroscience 2019-02-05 /pmc/articles/PMC6361622/ /pubmed/30805555 http://dx.doi.org/10.1523/ENEURO.0252-18.2018 Text en Copyright © 2019 Kalogeraki et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Kalogeraki, Evgenia
Yusifov, Rashad
Löwel, Siegrid
Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title_full Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title_fullStr Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title_full_unstemmed Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title_short Transgenerational Transmission of Enhanced Ocular Dominance Plasticity from Enriched Mice to Their Non-enriched Offspring
title_sort transgenerational transmission of enhanced ocular dominance plasticity from enriched mice to their non-enriched offspring
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361622/
https://www.ncbi.nlm.nih.gov/pubmed/30805555
http://dx.doi.org/10.1523/ENEURO.0252-18.2018
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