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Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361637/ https://www.ncbi.nlm.nih.gov/pubmed/30473572 http://dx.doi.org/10.1292/jvms.18-0619 |
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author | KHATUN, Afia SAKURAI, Masashi SAKAI, Yusuke TACHIBANA, Masato OHARA, Naoya MORIMOTO, Masahiro |
author_facet | KHATUN, Afia SAKURAI, Masashi SAKAI, Yusuke TACHIBANA, Masato OHARA, Naoya MORIMOTO, Masahiro |
author_sort | KHATUN, Afia |
collection | PubMed |
description | It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues produce α-defensin, an anti-bacterial peptide. We investigated in this study whether eosinophils reacting to mycobacteria produce α-defensin in mice and whether it can be used as a model. We showed that mycobacterial infection induced blood eosinophilia and infiltration of α-defensin producing eosinophils that to surround mycobacteria at the site of infection. These findings were usually seen during human mycobacterial infection. We established a good model to study host defense mechanism against mycobacteria through α-defensin via eosinophils. |
format | Online Article Text |
id | pubmed-6361637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63616372019-02-08 Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice KHATUN, Afia SAKURAI, Masashi SAKAI, Yusuke TACHIBANA, Masato OHARA, Naoya MORIMOTO, Masahiro J Vet Med Sci Pathology It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues produce α-defensin, an anti-bacterial peptide. We investigated in this study whether eosinophils reacting to mycobacteria produce α-defensin in mice and whether it can be used as a model. We showed that mycobacterial infection induced blood eosinophilia and infiltration of α-defensin producing eosinophils that to surround mycobacteria at the site of infection. These findings were usually seen during human mycobacterial infection. We established a good model to study host defense mechanism against mycobacteria through α-defensin via eosinophils. The Japanese Society of Veterinary Science 2018-11-23 2019-01 /pmc/articles/PMC6361637/ /pubmed/30473572 http://dx.doi.org/10.1292/jvms.18-0619 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Pathology KHATUN, Afia SAKURAI, Masashi SAKAI, Yusuke TACHIBANA, Masato OHARA, Naoya MORIMOTO, Masahiro Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title | Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title_full | Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title_fullStr | Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title_full_unstemmed | Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title_short | Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
title_sort | mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361637/ https://www.ncbi.nlm.nih.gov/pubmed/30473572 http://dx.doi.org/10.1292/jvms.18-0619 |
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