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Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice

It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues p...

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Autores principales: KHATUN, Afia, SAKURAI, Masashi, SAKAI, Yusuke, TACHIBANA, Masato, OHARA, Naoya, MORIMOTO, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361637/
https://www.ncbi.nlm.nih.gov/pubmed/30473572
http://dx.doi.org/10.1292/jvms.18-0619
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author KHATUN, Afia
SAKURAI, Masashi
SAKAI, Yusuke
TACHIBANA, Masato
OHARA, Naoya
MORIMOTO, Masahiro
author_facet KHATUN, Afia
SAKURAI, Masashi
SAKAI, Yusuke
TACHIBANA, Masato
OHARA, Naoya
MORIMOTO, Masahiro
author_sort KHATUN, Afia
collection PubMed
description It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues produce α-defensin, an anti-bacterial peptide. We investigated in this study whether eosinophils reacting to mycobacteria produce α-defensin in mice and whether it can be used as a model. We showed that mycobacterial infection induced blood eosinophilia and infiltration of α-defensin producing eosinophils that to surround mycobacteria at the site of infection. These findings were usually seen during human mycobacterial infection. We established a good model to study host defense mechanism against mycobacteria through α-defensin via eosinophils.
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spelling pubmed-63616372019-02-08 Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice KHATUN, Afia SAKURAI, Masashi SAKAI, Yusuke TACHIBANA, Masato OHARA, Naoya MORIMOTO, Masahiro J Vet Med Sci Pathology It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the role of eosinophils against the mycobacterium is unclear. We showed in previous study that in situ mouse eosinophils infiltrated into tissues produce α-defensin, an anti-bacterial peptide. We investigated in this study whether eosinophils reacting to mycobacteria produce α-defensin in mice and whether it can be used as a model. We showed that mycobacterial infection induced blood eosinophilia and infiltration of α-defensin producing eosinophils that to surround mycobacteria at the site of infection. These findings were usually seen during human mycobacterial infection. We established a good model to study host defense mechanism against mycobacteria through α-defensin via eosinophils. The Japanese Society of Veterinary Science 2018-11-23 2019-01 /pmc/articles/PMC6361637/ /pubmed/30473572 http://dx.doi.org/10.1292/jvms.18-0619 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
KHATUN, Afia
SAKURAI, Masashi
SAKAI, Yusuke
TACHIBANA, Masato
OHARA, Naoya
MORIMOTO, Masahiro
Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title_full Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title_fullStr Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title_full_unstemmed Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title_short Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
title_sort mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361637/
https://www.ncbi.nlm.nih.gov/pubmed/30473572
http://dx.doi.org/10.1292/jvms.18-0619
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